First Total Synthesis of Five Natural Prenylated Flavonoids
نویسندگان
چکیده
منابع مشابه
Prenylated Flavonoids from Pongamia pinnata
Pongamia pinnata (Leguminosae) is widely distributed along southeastern Asia to the west Pacific and north Australia. All parts of the plant have been used as crude drug for the treatment of tumors, piles, skin diseases, wounds, ulcers, etc. [1]. Extracts of the plant possess significant anti-diarrhoeal, anti-fungal, anti-plasmodial, anti-ulcerogenic, anti-inflammatory, analgesic activities [2 ...
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Two new prenylated flavonoids, named scariosin (1) and isorhynchospermin (2) were isolated from the leaves of paracalyx scariosa together with kaempferol, quercetin, kaempferol 3-O- rutinoside and rutin. The structures of (1) and (2) were characterized as 8-C- prenyl- taxifolin 7,3'-dimethylether and 6-C-prenylquercetin 7,4'-dimethylether by their chemical and spectra data, respectively.
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For the purpose of the development of a skin-whitening agent, Sophora flavescens was evaluated for tyrosinase inhibitory activity and its active principles were identified following activity-guided isolation. The ethanol extract and dichloromethane fraction from S. flavescens showed significant inhibition of mushroom tyrosinase. From the dichloromethane fraction, three known prenylated flavonoi...
متن کاملRare prenylated flavonoids from Tephrosia purpurea.
Chemical investigations of aerial parts of Tephrosia purpurea yielded the rare prenylated flavonoids, tephropurpulin A (1) and isoglabratephrin (2), in addition to a previously identified flavonoid, glabratephrin (3). Structures were established by 1D and 2D NMR spectroscopy, as well as by HR-MS analysis; for compounds 2 and 3, structures were confirmed by X-ray analysis.
متن کاملRegiospecific synthesis of prenylated flavonoids by a prenyltransferase cloned from Fusarium oxysporum.
Due to their impressive pharmaceutical activities and safety, prenylated flavonoids have a high potent to be applied as medicines and nutraceuticals. Biocatalysis is an effective technique to synthesize prenylated flavonoids. The major concern of this technique is that the microbe-derived prenyltransferases usually have poor regiospecificity and generate multiple prenylated products. In this wo...
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ژورنال
عنوان ژورنال: Chinese Journal of Organic Chemistry
سال: 2014
ISSN: 0253-2786
DOI: 10.6023/cjoc201406018